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Loxitane (Loxapine) is a tricyclic antipsychotic medication.

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Uses

Loxapine (LOX-a-peen) is used for treating schizophrenia.

How to take

Loxapine may be taken with or without food. Using Loxapine at the same times each day will help you to remember to take it. Continue to use Loxapine even if you feel well. Do not miss any doses.

Side effects

Check with your doctor if any of these most common side effects persist or become bothersome: Blurred vision, constipation, dizziness, drowsiness, dry mouth, headache, nausea, stuffy nose, trouble sleeping, vomiting, weight gain or loss. Seek medical attention right away if any of these severe side effects occur: Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation, altered mental abilities, including lack of response to your surroundings; chills or persistent sore throat; confusion, dark urine, decreased urination, fainting or faintness; fast or irregular heartbeat; hyperactivity, increased saliva production, increased thirst, involuntary, uncontrolled muscle movements; menstrual changes, mental or mood changes; muscle twitching, numbness or tingling of the skin; restlessness, seizures, shortness of breath; severe constipation, slurred speech, staggering or shuffling gait; stiff or rigid muscles; sweating, tremor, unexplained fever; vision changes, yellowing of the eyes or skin. Symptoms of overdose may include decreased urination, difficulty breathing; involuntary, uncontrolled muscle movements; loss of consciousness, seizures, severe or persistent dizziness. If you suspect an overdose of Loxapine, seek medical attention immediately.

Precaution

Do NOT use Loxapine if you are allergic to any ingredient in Loxapine or to other similar medicines;
you have severe central nervous system depression (eg, severe drowsiness), or have been sedated; you are taking sodium oxybate (GHB).
Contact your doctor or health care provider right away if any of these apply to you.
Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
If you are pregnant, planning to become pregnant, or are breast-feeding;
If you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement;
If you have allergies to medicines, foods, or other substances;
If you have a history of other mental problems, heart problems, glaucoma, difficulty urinating or risk factors for difficult urination, Parkinson disease, breast cancer, liver problems, brain growths or cancer, a stomach blockage, or seizures;
If you are very ill or weakened;
If you are dependent on alcohol or drink large amounts of alcohol regularly.
Loxapine may cause drowsiness, dizziness, or blurred vision. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Loxapine.
Using Loxapine alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Loxapine. Loxapine will add to the effects of alcohol and other depressants.
Do not become overheated in hot weather or during exercise or other activities because heatstroke may occur.
Neuroleptic malignant syndrome (NMS) is a potentially deadly syndrome associated with Loxapine.
Symptoms include: increased body heat; muscle rigidness; altered mental abilities, including lack of response to your surroundings; irregular pulse and blood pressure; increased heart rate; sweating; irregular heart rhythm. Contact your doctor at once if any of these symptoms occur.
Involuntary and uncontrollable movements may develop in patients taking Loxapine. Occurrence is highest among the elderly, especially women. The risk of developing these involuntary muscle movements and the likelihood they will become permanent are increased with long-term use and with high doses. However, it is possible to develop these symptoms after short-term treatment at low doses.
Contact your health care provider at once if any of the following occur: Involuntary movements of the tongue, face, mouth, or jaw (eg, protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements), sometimes accompanied by involuntary movements of the arms and legs.
Use Loxapine with caution in the elderly because they may be more sensitive to its effects, especially involuntary muscle movements.
If you become pregnant, discuss with your doctor the benefits and risks of using Loxapine during pregnancy. It is unknown if Loxapine is excreted in breast milk. If you are or will be breast-feeding while you are using Loxapine, check with your doctor or pharmacist to discuss the risks to your baby.

Drug interactions

Tell your health care provider if you are taking any other medicines, especially any of the following: Barbiturates (eg, phenobarbital), narcotics (eg, codeine), or sodium oxybate (GHB) because the risk of side effects, such as severe drowsiness, may be increased; Anticholinergics (eg, trihexyphenidyl) because side effects of Loxapine may be increased; Benzodiazepines (eg, lorazepam) because side effects may be increased by Loxapine. This may not be a complete list of all interactions that may occur. Ask your health care provider if Loxapine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Missed dose

If you miss a dose of Loxapine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Storage

Store Loxapine at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Loxapine out of the reach of children and away from pets.