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UsesZidovudine is used for the treatment of HIV and the prevention of HIV transmission from an infected mother to her fetus. How to takeStudies indicate that possible blood cell damage may be prevented or treated by taking vitamin E, epoeitin alpha (EPO) or G-CSF with this drug. Zidovudine is best taken on an empty stomach. If you have stomach irritation, zidovudine may be taken with food. The capsules can be broken open and mixed with food right before eating if you have trouble swallowing. Nutritionists recommend taking manganese and B vitamins with this drug. Side effectsLong-term zidovudine use is associated with loss of muscle. Other side effects can be anemia, white blood cell depression, lip, mouth and tongue sores, bone marrow damage, headaches, skin rash, itching, weakness, nervousness, dizziness, nausea, stomach pain, confusion, loss of speech or appetite, muscle aches, fever or sweating, sore throat or abnormal bruising or bleeding. In African-Americans, zidovudine can cause changes in nail color. PrecautionBefore you take zidovudine, tell your doctor if you have a history of anemia, bleeding or blood problems, liver or kidney disease, heart disease, major injury/surgery/infection, alcoholism, any allergies. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Avoid breast-feeding to prevent transmission of HIV to a child that may not be infected. Zidovudine is excreted into human milk. Drug interactions· Zidovudine should not be combined with Zerit (d4T). They are "antagonistic," which means that they do not work well together and can cause additional side effects. Missed doseIf you miss a dose, take as soon as remembered; do not take if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up. StorageStore at room temperature between 59 and 86 degrees F (between 15 and 30 degrees C) away from moisture and sunlight. Do not store in the bathroom. Keep away from children and pets. |